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In this review, we discuss current findings regarding piRNA biogenetic processes, functions, and emerging roles in cancer, providing new insights regarding the potential applications of piRNAs and sitez proteins in cancer diagnosis and clinical treatment. They were first described in in Drosophila testes as small RNAs derived from the Advetrising Ste tandem repeats, which silence Stellate transcripts to maintain male fertility [ 2 ].
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